New Study on Application of Gallic acid

Background and overview : 

Gallic acid (GA), also known as gallate, is a kind of natural product chemical composition, named 3,4,5-trihydroxybenzoic acid, which has high medicinal value. It is widely found in rhubarb, eucalyptus, Cornus officinalis, chelidae, Coriaria, Sapium, pomegranate, yellow rush, Acacia and other plants. It is a kind of polyphenol compound in nature. Gallic acid, also known as gallate and acid, is a white or yellowish needle like crystal or powder, usually in the form of monohydrate.

Therefore, a variety of derivatives related to gallic acid can be prepared. Researchers continue to find the pharmacological effect of gallic acid, and carried out in-depth research to make it widely used in clinical. 


1. Antitumor effect:

1) Inhibition of tumor formation; 

2) Cytotoxic effect: gallic acid can inhibit and directly kill tumor cells;

3) Inhibition of tumor angiogenesis;

4) GA, as a polyphenol, has strong antioxidant and anti free radical effects; 

5) Induction of tumor cell apoptosis. 

2. Effect on liver:

Researchers in China believe that GA has the effect of anti HBV.

It can be seen that GA is an effective anti HBsAg / HBeAg drug screened in the laboratory. 

3. Effect on blood vessels:

The vascular effects of GA on rat thoracic aorta were studied.

These results show that GA induced endothelium-dependent contraction and endothelium-dependent relaxation, rather than endothelium-independent relaxation, may be through inhibition of no production in endothelium.

4. Prevention and treatment of AIDS:

Gallic tannin is an ester formed by gallic acid and Polyols (such as glucose, quinic acid, shikimic acid, etc.). Gallic tannin is one of the main varieties of tannin used in the study of resistance to HIV. 

5. Trypanosome killing effect:

Trypanosoma Africana is a flagelliform parasite that causes sleep disorders in humans and animals. GA has strong insecticidal effect on both blood flow type and anterior circulation type trypanosomes.

Post time: Mar-24-2020